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IUI Stands for Intra Uterine Insemination. It is a procedure that involves placing sperm inside a woman’s uterus to facilitate fertilization. The doctor uses a catheter to place a number of washed sperm directly into the uterus. The goal of IUI is to increase the number of sperm that reach the fallopian tubes and subsequently increase the chance of fertilization.

Few Frequently Asked Questions About IUI

IUI is painless atraumatic deposition of sperms in the uterine cavity around the time of ovulation.

1. Bypassing the cervical barrier

2. To deposit good quality & quantity of sperms in the uterine cavity.

3. To identify the ovulation timing.

1. Ovulating female i.e. presence of eggs in the ovaries (patient aged more than 35 years should check their ovarian reserve before IUI by means of hormonal tests i.e. AMH .

2. At least one patient Fallopian Tube (is checked either by HSG or Laparoscopy).

3. Semen sample should contain sufficient numbers of good quality sperms. Check sperm yield & morphology percentage in semen analysis report.

  • Ideal sperm yield for IUI → 5×10⁶ or more
  • Minimum sperm yield at which IUI can be tried →2×10⁶
  • Minimum normal sperm percentage→ 4%

1. Patient with Ovulatory Dysfunction e.g., PCOS

2. Patient with mild Endometriosis

3. Patient with Unconsummated Marriage.

4. Immunological Abnormalities.

5. Patient with decreased sperm count.

6. Patient with ejaculatory dysfunctions.

7. Unexplained infertility.

Your doctor gives you medications for OI for egg formation. Then the female partner only has to come on Day 10 or Day 11 of menstruation for FM. Follicular Monitoring (FM) is the assessment of growth of egg by sonography. Once the egg is matured, one injection (HCG 10000 i.u) is given for the egg to come out of the ovary (Ovulation). IUI proper is done, 24 hours 48 hours after HCG injection. The prepared semen are put inside the uterus using a non-traumatic cannula. The whole process is very simple and not painful. Sometimes your doctor may decide to do single IUI, at around 36 hours after injection.

Pregnancy rates following IUI depends on the indications for IUI. Best results are obtained in patients with unexplained infertility, ovulatory dysfunction, unconsummated marriage or patients with ejaculatory dysfunction.In these cases pregnancy rate per cycle can go upto 15-20%. In other words almost 70-80% couples can expect pregnancy in 6 cycles of IUI. In patients with endometriosis or decreased sperm count pregnancy rate decreases depending upon the severity of the disease.

Medications are given to produce eggs. This is known as Ovulation Induction. In modern infertility management IUI cycles are mostly done with OI. Usually oral drugs like Clomophine Citrate(C.C) or letrozole alone or along with some other drugs is used for OI.But in some patients your doctor might choose to give you few hormone injections too.

No hospitalization or rest is required during or after the procedure.the whole procedure is very simple and painless.The female partner has to stay OPD for two to three hours during the days of F.S. on the days when insemination is done, the female partner may have to stay at OPD for 3-4 hours. On the days of insemination the male partner can just come and give semen and go back. After insemination, she will take rest on the IUI table for 15 minutes only. No rest is required after finishing the process. The female partner can do routine household work, can travel, can go to work or practically can do all the activities which she is used to do.

Donor insemination is indicated in case of:

1. Male factor Infertility

a. Azospermia with primary testicular failure.

b. Subnormal sperm parameters like severe, Oligo,Astheno, and/or terato zoospermia & Azoospermia. (when patient cannot afford IVF/ICSI or TESE or TESA-ICSI)

2. Risk of transmission of genetic diseases from the male partner.

3. Those who have had multiple failure at ICSI or TESE-ICSI

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